Dicarboxylic acids and derivatives
Selleck Chemical LLC MG-101
MG-101 (ALLN Calpain inhibitor-1 Ac-LLnL-CHO) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins
Selleck Chemical LLC PHI-101-E1437-100MG
PHI-101 is an orally active potent third-generation inhibitor of FLT3 that overcomes resistance to multiple drug-resistant mutations It has potential for research in relapsed or refractory acute myeloid leukemia (AML)
Medchemexpress LLC Calpain inhibitor I | 110044-82-1 | ≥98.0% | 383.53 | 25 MG
MG-101 (ALLN) is an inhibitor of cysteine proteases, specifically inhibiting calpain I, calpain II, cathepsin B, and cathepsin L with Kis of 190, 220, 150, and 500 pM, respectively. It induces apoptosis and inhibits tumor growth, and can be used for research on colon cancer.
- Inhibits calpain I, calpain II, cathepsin B, and cathepsin L.
- Induces apoptosis.
- Inhibits tumor growth.
- Affects the growth of colon cancer HCT116 cells.
- Induces Bax-dependent apoptosis in HCT116 cells.
- Useful for research on colon cancer.
- Demonstrates efficacy in inhibiting tumor growth in nude mice.
Medchemexpress LLC 4H-1-Benzopyran-3-carbonitrile, 2-amino-5,6,7,8-tetrahydro-4-(4-methoxyphenyl)-7-(1-naphthalenyl) | 1118460-77-7 | 98.61% | 422.48 | 100 MG
UCPH-101 is a potent excitatory amino acid transporter subtype 1 (EAAT1) inhibitor, demonstrating an IC50 of 0.66 μM. This compound is intended for research applications only and is not suitable for patient use.
- Inhibits EAAT1 anion currents with a KD value of 0.34±0.03 μM (Hill=1.3±0.13, n≥9).
- Causes a small but significant decrease in total expression levels of HA-EAAT1 and HA-GLAST in cells preincubated with 100 μM UCPH-101 (p=0.048).
Medchemexpress LLC UCPH-101 excitatory amino acid transporter subtype 1 inhibitor | 1118460-77-7 | 98.6% | 422.48 | 1 ML
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. This compound is suitable for research applications. It presents as a white to off-white solid.
- Molecular weight: 422.48
- Formula: C27H22N2O3
- Appearance: Solid
- Color: White to off-white
- Shipping: Room temperature in continental US (may vary elsewhere)
- Storage: Powder at -20°C for 3 years or 4°C for 2 years; in solvent at -80°C for 2 years or -20°C for 1 year
- Solubility: In DMSO: ≥ 50 mg/mL (118.35 mM)
Medchemexpress LLC Lei 101 hydrochloride | 2250025-91-1 | 99.4% | 508.99 g/mol | C23H26ClFN4O4S | 10MM 1ML
LEI-101 hydrochloride is a potent, selective, orally bioavailable cannabinoid CB2 receptor agonist used for receptor pharmacology and preclinical research. It is provided in both solid form and as a ready-to-use DMSO solution to support biochemical and cellular assays.
Medchemexpress LLC 1,2-Dilauroyl-sn-glycerol | 60562-15-4 | 98.0% | 50 MG
1,2-Dilauroyl-sn-glycerol is a saturated diacylglycerol that may be involved in second messenger signal transduction. It appears as a white to off-white solid with a molecular formula of C27H52O5 and a molecular weight of 456.70. This product is intended for research use only.
- Purity of 98.0%
- CAS number: 60562-15-4
- Soluble in DMSO (100 mg/mL), requiring ultrasonic for dissolution
- Ships at room temperature within the continental US
- Recommended storage for powder: -20°C for 3 years
- Recommended storage for in-solvent solutions: -80°C for 6 months, or -20°C for 1 month (aliquot and store to prevent inactivation from repeated freeze-thaw cycles)
- Related to metabolic enzymes/proteases and endogenous metabolites
- Acts as an inhibitor
Apexbio Technology LLC CAL-101 (Idelalisib, GS-1101) 870281-82-6 100mg
CAL-101 (Idelalisib GS-1101 CAS 870281-82-6) is a selective inhibitor targeting the p110 isoform of phosphatidylinositol 3-kinase (PI3K) an enzyme involved in signaling pathways critical for proliferation and survival of malignant B cells By inhibiting PI3K p110 CAL-101 reduces PI3K-mediated phosphorylation of Akt and other downstream factors leading to enhanced PARP cleavage and caspase activation ultimately inducing apoptosis in malignant B cells CAL-101 has been demonstrated to counteract survival signals initiated by molecules such as CD40 ligand (CD40L) TNF- and fibronectin This agent is valuable in investigating B-cell malignancies
Selleck Chemical LLC CUDC-101 S1194-10mM/1mL
CUDC-101 is a potent multi-targeted inhibitor against HDAC EGFR and HER2 with IC50 of 4 4 nM 2 4 nM and 15 7 nM and inhibits class I/II HDACs but not class III Sir-type HDACs Phase 1
Medchemexpress LLC Lauroyl-L-carnitine chloride | 6919-91-1 | 98.1% | 1 ML
Lauroyl-L-carnitine chloride is an orally active metabolite that significantly reverses the decrease in its target gene IL-10 and alleviates Crohn's-like colitis. This product is for research use only.
- Orally active metabolite
- Reverses decrease in IL-10
- Alleviates Crohn's-like colitis
- Exhibits anti-inflammatory effects
- Improves systemic and local phenotypes of TNBS mice
Medchemexpress LLC Lauroyl-L-carnitine (chloride) | 6919-91-1 | 98.1% | 1 MG
Lauroyl-L-carnitine chloride is an orally active metabolite that significantly reverses the decrease in its target gene IL-10, alleviating Crohn's-like colitis. It demonstrates anti-inflammatory effects and improves both systemic and local phenotypes in TNBS mice.
- Orally active metabolite
- Reverses decrease in target gene IL-10
- Alleviates Crohn's-like colitis
- Exhibits anti-inflammatory effects
- Improves systemic and local phenotypes in TNBS mice
eMolecules Diethyl 2,2-thiodiacetate | Ambeed | 925-47-3 | MFCD00087932 | 206.260 | C8H14O4S | 98.000 | CCOC(=O)CSCC(=O)OCC | 5g | 600849984
Diethyl 2,2-thiodiacetate | Ambeed | 925-47-3 | MFCD00087932 | 206.260 | C8H14O4S | 98.000 | CCOC(=O)CSCC(=O)OCC | 5g | 600849984
Medchemexpress LLC UCPH-101 | 1118460-77-7 | 98.6% | 422.48 | 10 MG
UCPH-101 is an excitatory amino acid transporter subtype 1 (EAAT1) inhibitor with an IC50 of 0.66 μM. It functions as an allosteric modulator, inducing sustained inhibition of EAAT1 through an intramonomeric site within the trimerization domain. In vitro studies show that UCPH-101 inhibits EAAT1 anion currents in a concentration-dependent manner, with a KD value of 0.34±0.03 μM. This compound is intended for research use only.
- Inhibits excitatory amino acid transporter subtype 1 (EAAT1)
- Functions as an allosteric modulator
- Demonstrates sustained inhibition of EAAT1 anion currents
- IC50 of 0.66 μM
- KD value of 0.34±0.03 μM for EAAT1 anion currents